解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::As rat tracheal epithelial cells progress from a normal to a neoplastic phenotype there are systematic changes in their ability to produce and activate latent transforming growth factor type beta (TGF-beta) as well as systematic changes in their response to this growth factor. Using a TGF-beta radioreceptor binding co...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.6.973
更新日期:1989-06-01 00:00:00
abstract::The influence of the smoking parameters (puff profile, puff duration, puff volume, puff frequency) on the delivery of tobacco-specific nitrosamines (TSNAs) in mainstream smoke was investigated for six different cigarette brands, including filter cigarettes with very low to medium smoke yields and non-filter cigarettes...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.6.1059
更新日期:1989-06-01 00:00:00
abstract::Isolated trout liver cells were treated with lysolecithin to produce an in situ system for characterizing DNA repair in teleosts. In this preparation, the integrity of the plasma membrane is altered, nuclei remain intact, and the concentrations of dNTPs and nucleotide analogs, which normally do not penetrate intact pl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.6.995
更新日期:1989-06-01 00:00:00
abstract::The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.5.833
更新日期:1989-05-01 00:00:00
abstract::The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.5.949
更新日期:1989-05-01 00:00:00
abstract::The effects of dietary Brussels sprouts and indole-3-carbinol (I3C) on xenobiotic-metabolizing enzyme activities and hepatic aflatoxin B1 (AFB1)-DNA binding were determined in rats. Animals were dosed intraperitoneally (i.p.) or intragastrically (i.g.) with [3H]AFB1 and killed 2 (i.p.) or 3 (i.g.) h later. Brussels sp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.4.629
更新日期:1989-04-01 00:00:00
abstract::N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) was administered i.p. to male Wistar rats 17 h after partial hepatectomy. Hepatocytes were analyzed for the presence of micronuclei 7 h, 1, 2, 3 and 4 days after injection. N-OH-AAF treatment resulted in a high frequency of micronucleated hepatocytes at days 3 and 4 (19.5% an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.4.717
更新日期:1989-04-01 00:00:00
abstract::Macrophages and their immortalized cell lines can be activated to form nitrite and nitrate via oxidation of arginine and this is accompanied by the formation of N-nitroso compounds. The mechanism of nitrosamine formation has been investigated through the use of compounds which are known either to inhibit or enhance ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.563
更新日期:1989-03-01 00:00:00
abstract::Two of the major bacterial mutagens formed in heated meat products, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or the basic fraction of beef extract induced a low frequency of sister chromatid exchanges in human lymphocyte cultures in the presence of metabolic activation....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.429
更新日期:1989-03-01 00:00:00
abstract::The antihistamine methapyrilene (hydrochloride) and four close structural analogs, methaphenilene, methafurylene, thenyldiamine and clorothen, were given to rats at a concentration of 0.1% in drinking water for 34 weeks. Only methapyrilene produced notable histopathological changes in the liver, bile duct hyperplasia ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.557
更新日期:1989-03-01 00:00:00
abstract::Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.493
更新日期:1989-03-01 00:00:00
abstract::An antibody (anti-EH) specific for microsomal epoxide hydrolase (mEH) from rhesus monkey liver has been used to test the immunochemical relationship between human liver mEH and the serum EH levels in human patients with hepatocellular carcinoma (HCC). Immunoblots of separated rhesus monkey and human liver microsomal p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.343
更新日期:1989-02-01 00:00:00
abstract::Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.283
更新日期:1989-02-01 00:00:00
abstract::The genotoxic effects of intragastrically administered benzo[a]pyrene (BaP) were studied in isolated rat liver and intestinal cells. We found that BaP was unable to induce unscheduled DNA synthesis in rat parenchymal liver cells in vivo. In contrast, alkaline elution showed that at 5 h after administration of BaP a co...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.393
更新日期:1989-02-01 00:00:00
abstract::Fifty-five types of commercial cigarettes on the West German market were analyzed for tobacco-specific nitrosamines (TSNA) in mainstream smoke. The cigarettes included filter and nonfilter cigarettes with very high, high, medium, low and ultra-low tar and nicotine yields. The observed range for N'-nitrosonornicotine w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.169
更新日期:1989-01-01 00:00:00
abstract::The 32P-postlabeling method has been adapted for the analysis of thymidine-cis-glycol-3'-phosphate (cis-dTGp,cis-5,6-dihydroxy-5,6-dihydrothymidine-3'-phosphat e). Cis-dTGp was isolated and purified from normal nucleotides by phenylboronate affinity chromatography and phosphorylated by T4 polynucleotide kinase in pres...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.43
更新日期:1989-01-01 00:00:00
abstract::We have compared the regulation of ornithine decarboxylase (ODC) gene expression in primary cultures of hamster embryo fibroblasts and in two independently transformed hamster embryo cell lines. Previous studies have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) can greatly potentiate the serum growth f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.157
更新日期:1989-01-01 00:00:00
abstract::We present data showing that the major phenobarbital inducible cytochromes P-450 (cytochrome P-450IIB1 and cytochrome P-450IIB2) were phosphorylated in intact hepatocytes. This phosphorylation was greatly increased by the cAMP derivatives N6-dibutyryl-cAMP and 8-thiomethyl-cAMP mediated by a cAMP-dependent protein kin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.225
更新日期:1989-01-01 00:00:00
abstract::The ability of dietary retinyl palmitate, canthaxanthin or the combination of both, to prevent induction of immunosuppression by UVB irradiation was tested by passive transfer of splenocytes. The basal diet was the American Institute of Nutrition diet 76A, containing 4 IU retinyl palmitate/g diet. Groups of 55 mice we...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.1.203
更新日期:1989-01-01 00:00:00
abstract::Using conventional alkaline sucrose sedimentation analysis, we have compared the initial yield and subsequent enzymatic repair of DNA damage induced in cultured human [normal (GM38 and GM43) and xeroderma pigmentosum (XP12BE)] fibroblasts by the monofunctional alkylating agent methylmethanesulfonate (MMS). Exposure of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.12.2257
更新日期:1988-12-01 00:00:00
abstract::The effect of the protease inhibitor antipain (1.25 micrograms/ml) on the radiation-induced expression of a tumor-associated antigen in human cell hybrids has been investigated. A variety of treatment protocols have been studied where antipain was present before, during and at various times post-irradiation. It was fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.12.2333
更新日期:1988-12-01 00:00:00
abstract::Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.12.2325
更新日期:1988-12-01 00:00:00
abstract::One of the most widely studied ultimate carcinogens, 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I), is fairly stable in organic solvents but hydrolyses rapidly in the presence of water. Routine use of BPDE-I stock solutions involves multiple cycles of warming to room temperature and return to f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2133
更新日期:1988-11-01 00:00:00
abstract::Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.1915
更新日期:1988-11-01 00:00:00
abstract::We have previously reported the disposition of benzo[a]pyrene (B[a]P) and its metabolites in male Sprague-Dawley rats following intratracheal instillation of [3H]B[a]P [Weyand, E.H. and Bevan, D.R. (1986) Cancer Res., 46, 5655-5661]. In some experiments, cannulas were implanted in the bile duct of the animals prior to...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2027
更新日期:1988-11-01 00:00:00
abstract::The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2137
更新日期:1988-11-01 00:00:00
abstract::Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.10.1785
更新日期:1988-10-01 00:00:00
abstract::We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.10.1727
更新日期:1988-10-01 00:00:00
abstract::The carcinogen N-acetoxy-N-2-acetylaminofluorene reacts with dG and dG-containing nucleotides to give good yields of the C-8 adducts, but the analogous 4-aminobiphenyl derivative does not. Replacement of the N-acetoxy group by 2,6-dichlorobenzoyloxy circumvents this difficulty. This reaction is shown to be generally a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.10.1817
更新日期:1988-10-01 00:00:00
abstract::One of the peaks present in HPLC profiles of [3H]benzo[a]-pyrene (BaP)-deoxyribonucleosides prepared by enzymatic degradation of [3H]BaP-DNA isolated from Wistar rat embryo cell cultures exposed to [G-3H]BaP was found to be r-7,c-9,c-10,t-8-tetrahydroxy-7,8,9,10-tetrahydroBaP, a BaP-DNA adduct decomposition product (P...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.10.1863
更新日期:1988-10-01 00:00:00
abstract::Quantum and molecular mechanical calculations were employed to examine the effect on binding energies and structure of methylation and ethylation at O6-guanine in double-stranded DNA. Ab initio quantum chemical calculations (STO-3G, 3-21G) were initially used to pseudo-optimize the structure of the 9-methyl derivative...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.9.1553
更新日期:1988-09-01 00:00:00
abstract::Alkylation of DNA and hemoglobin was compared in male F344 rats given a single s.c. injection of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), or its major metabolite formed by carbonyl reduction, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). In hepatic DNA, levels of 7...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.9.1665
更新日期:1988-09-01 00:00:00
abstract::We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.8.1347
更新日期:1988-08-01 00:00:00
abstract::The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.8.1437
更新日期:1988-08-01 00:00:00
abstract::DNAs from fourteen fibrosarcomas induced by 3-methylcholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K-ras and two c-N-ras. These results demonstrate that c-K-ras is ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.8.1517
更新日期:1988-08-01 00:00:00
abstract::O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.7.1217
更新日期:1988-07-01 00:00:00
abstract::The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.7.1307
更新日期:1988-07-01 00:00:00
abstract::The potential carcinogenic activity of 5,6-dimethoxysterigmatocystin (DMSC) was examined by oral administration in rats. In Experiment I, all of eight effective ACI/N rats given DMSC in the diet at a concentration of 50 p.p.m. developed neoplastic nodules of the liver. Five rats developed hepatocellular carcinomas and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.6.1039
更新日期:1988-06-01 00:00:00
abstract::Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/9.6.875
更新日期:1988-06-01 00:00:00
abstract::The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.6.1061
更新日期:1988-06-01 00:00:00